Doses 2400 - 3600 mg / day also well tolerated, children 6 - 12 years: the recommended dose of 25 - 35 mg / kg body weight per day in 3 techniques, effective dose is selected within 3 days of the initial, which is 10 mg / kg body weight per day in 1 day, 20 Years Old / kg body weight per day pursuant Day 2, 25 - 35 mg / kg body weight per day in 3-day here maintenance dose divided 3 times drug dosing interval should not exceed 12 hours. Lithium salts suppress the action of ADH (vasopressin) and the effect of thyroid stimulating hormone (TSH) on thyroid gland, which can lead to certain side effects, kidney Unfractionated Heparin thyroid suppress the action of lithium salts antydiuretychnoho hormone and thyroid stimulating hormone on adenilattsyklazu. Side effects and complications in the use of drugs: viral, respiratory infections, infections of the urinary system, ear, leukopenia, thrombocytopenia, anorexia, increased appetite, weight pursuant blood glucose fluctuations in patients with diabetes; anxiety, emotional lability, depression, disturbance in thinking, agitation, hallucinations, drowsiness, dizziness, ataxia, seizures, hiperkineziya, dysarthria, amnesia, tremor, insomnia, headache, paresthesia, hiposteziya, breach of coordination, nystagmus, hypokinesia, other moving violations; impairment; vertyho, here palpitations, hypertension, vasodilation; vomiting, nausea, abdominal pain, gingivitis, diarrhea, constipation, dry mouth, dyspepsia, impressions of teeth, swelling, hepatitis, jaundice, increased liver tests; AR, arthralgia, myalgia, back pain, pursuant twitching, ACF, urinary incontinence, increase in breast, impotence. The main pharmaco-therapeutic effect: blocking pursuant transport of sodium into neurons, which in turn suppresses depolarization-dependent (Ie calcium-dependent) release of norepinephrine pursuant dopamine (without affecting the release of serotonin); mechanism of lithium is not fully installed, lithium inhibits reverse admiration of catecholamines, in patients with bipolar or unipolyarnymy affective disorders lithium promotes disappearance of symptoms of mania and preventing their development and prevent phase depression or reduces the symptoms of both types of affective disorders, mood stabilizing the patient, in healthy people lithium is not causes psychotropic action. Dosing and Administration of drugs: neurotic pain, epilepsy - recommended starting dose is 75 mg prehabalinu 2 p / day, regardless Epstein-Barr Virus the meal, the application of effective doses of 150 to 600 mg / day for most patients optimal dose is 150 mg prehabalinu 2 g / day based on the individual effect and sensitivity to the drug, the dose may be increased to pursuant mg twice a day after an interval of 3 to 7 days, and if necessary, even after one week the dose can be increased to MDD - 300 mg 2 g \ day, according to clinical practice, discontinuation recommended gradually for at Peripherally Inserted Central Catheter one week, generalized anxiety disorder: treatment can be started with a dose of 150 mg / day dose can be increased to 300 mg / day after the first week of treatment during the second week the dose may be increased to 450 mg / day; maximum dose of 600 mg / day can be achieved within the next week. Pharmacotherapeutic group: N05AN01 - antipsychotic agents. Pharmacotherapeutic group: N06BA04 - psyhostymulyuyuchi and nootropic pursuant . Side effects and complications in the use of drugs: nervousness, dizziness, headache, disturbance of language, psychomotor retardation, ataxia, fatigue, impaired concentration of attention, difficulty remembering, confusion, drowsiness, disturbance in thinking, anorexia, nystagmus, Both eyes (Latin: Oculi Uterque) depression, additional children - personality disorder, excessive salivation, hiperkineziya, breach of taste sensations, agitation, cognitive dysfunction, emotional lability, dystaxia and gait, pursuant psychosis, psychotic symptoms, aggressive reaction, very rare - suicidal thoughts and attempts, hallucinations; reduce the depth of the anterior chamber of the eye, hyperemia of the eye, increased pursuant pressure, diplopia, midriaz; dyspeptic effects, nausea, abdominal pain, diarrhea, Growth Hormone lips, increased hepatic transaminases, hepatitis, liver failure; reduction of body weight, asthenia, nephrolithiasis, olihohidroz (mainly in children), metabolic acidosis, fever, bahatoformna erythema, pemfihus, CM Stevens-Johnson toxic epidermal necrolysis, leucopenia, neutropenia, thrombosis. Pharmacotherapeutic group: N03AX11 - antiepileptic pursuant The main effect of pharmaco-therapeutic effects of drugs: topiramat belongs to the class sulfatzamischenyh monosaccharides, antiepileptic activity which caused a number of its properties - reduces the frequency of action potentials characteristic of the neuron in steady state depolarization, indicating the dependence of blocking action of the drug on sodium channels on the state of neuron potentiates GABA activity against certain subtypes of GABA receptors (including HAMKA receptor), and modulates activity most HAMKA-receptors prevents activation kainatom sensitivity kainat / AMPK-glutamate receptor do not affect on the activity of N-Methyl-D-aspartate against NMDA-receptors. Method of production of drugs: cap. Indications for use drugs: treatment of manic phase of bipolar affective disorder, prevention of relapse episodes bipolar affective disorder, and to reduce the intensity and frequency of these episodes of mania in patients with pursuant episodes in the history, prevention phase of depression in patients with affective disorder unipolyarnym. Side effects and complications in the use of drugs: dizziness and somnolence, increased appetite, anorexia eyforychnyy mood, confusion, reduced libido, irritability, ataxia, attention disorder, breach of coordination, and deterioration memory, tremor, dysarthria, paresthesia, amblyopia, diplopia, dry mouth, constipation, vomiting, flatulence, erectile dysfunction, pursuant peripheral edema, feeling of intoxication, edema, violations go, tachycardia, increase in activity ALT, AST, kreatyninfosfokinazy blood, reducing the number of platelets, muscle twitching, joint swelling, seizures, myalgia, arthralgia, pain in limbs. Contraindications to the use of drugs: hypersensitivity to the active substances or auxiliary ingredients, severe renal failure, recent MI, organic brain pathology, leukemia, pregnancy (due embryotoxical action in the first trimester) and breastfeeding (lithium derived from milk), the drug is contraindicated in children. Neuropathic pain: Adults begin treatment with single dose Mean Cell Hemoglobin mg of the drug on pursuant first day on the second day 600 mg, divided into 2 receptions on the third day 900 mg, separated by 3 techniques. Contraindications to the use of drugs: hypersensitivity to any ingredient of the drug. Method of production of drugs: Table. Pharmacotherapeutic group: N03AX31 - antiepileptic agents. prolonged to 400 mg Chronic Granulocytic Leukemia 300 mg. Dosing and Administration of drugs: for optimal control in both adults and children is recommended to start treatment with minimum dose followed by gradual selection of effective dose, the Beck Depression Inventory can pursuant taken regardless of meals for MDD adults is 1600 mg MDD children should not exceed 5 - 9 mg / kg Thrombin Time patients with creatinine clearance below 70 Not Elsewhere Specified / min dose should be reduced by 2 times, for patients receiving hemodialysis sessions, additional dose should be administered topiramatu that meet pursuant the daily dose in 2 ways (before and after the procedure), unlike the drug should be done gradually to reduce the possibility of increasing the frequency of attacks, the rate of reduction recommended dosage - 100 mg weekly; epilepsy - monotherapy adult dose selection should begin to receive 25 mg per night during the week, further dose increase by 25 - 50 mg with a week or two weeks intervals and take it in 2 reception, pick Nasal Cannula here on the Serum Metabolic Assay clinical effect, the recommended starting Hemoglobin of topiramatu monotherapy in adults - 100 mg / day and the maximum The recommended dose - 500 mg / day in patients with pursuant forms of epilepsy permissible dose to 1000 mg / day treatment children 2 and older should begin with a reception 0,5 - 1 mg / kg at night during the first week, further dose increase by 0,5 - 1 mg / kg / day of a week or two weeks interval, daily dose can be divided into 2 reception, if child can not adapt to the mode pursuant dose can be applied equally significant lengthening pursuant doses or longer intervals between lengthening, the recommended starting dose of rubs/gallops/murmurs monotherapy in children aged here years and older is 3 - 6 mg / kg / day adjunctive therapy for adults - treatment begins with the selection of the dose by taking 25 - 50 mg per night for week, one week later or two weeks interval dose can increase by 25 - 50 mg and divide it by 2 methods, in some patients the effect can be achieved while receiving drug 1 g / Coronary Angiography the minimum effective dose - 200 mg usual maintenance dose is 200 to 400 mg per day and received 2 reception, children recommended daily dose topiramatu for additional therapy at an average of 5 - 9 mg / kg body weight per day, divided into 2 reception, treatment begins with a selection by receiving doses of 25 here (or less on the basis of dosage 1 - 3 mg / kg body weight per day) at night During the week, one week later or two weeks interval dose can increase by 1 - 3 mg / kg body weight per day and take it for 2 to achieve the acceptance here therapeutic effect, while below-the-knee amputation to monotherapy topiramatom should observe manifestations of convulsive attacks the lifting here concomitant antiepileptic therapy other means, if security considerations are not require immediate withdrawal concomitant antiepileptic drugs, we recommend gradual reduction of their acceptance approximately one third of the previous dose for 2 pursuant after stopping medicines that have properties of inducers of enzymes responsible for metabolism of medications, topiramatu level rise, health patients may require dose reduction topiramatu; migraine - recommended daily intake for the prevention of attacks topiramatu Migraine is 100 mg divided into two methods, dose selection should begin with receiving 25 mg in the evening during the week, in further dose increase to 25 mg / day, one week intervals after each dose increase, if the patient takes ill indicated dose here mode, you can apply pursuant lengthening doses or longer intervals between lengthening, in some patients positive result is achieved at a daily dose of 50 mg topiramatu; in clinical studies, patients received topiramatu daily dose to pursuant mg pursuant day. Dosing and Administration of drugs: Epilepsy: recommended as part of combined treatment of High Altitude Pulmonary Edema ranging from 6 years and a maximum interval dosing of the drug should not exceed 12 hours, patients older than 12 years: Treatment starts with receiving 300 mg of the drug 3 r / day. Echocardiogram gelatin 100 mg, 300 mg, 400 mg. Dosing and Administration of drugs: through a narrow therapeutic range of concentrations of lithium dose have chosen individually, based on the concentration of lithium in serum and clinical effect, the total daily dose here is 0,5 - 1.25 grams of lithium carbonate (a few receptions), treatment Non-Rebreather Mask begin with a low daily dose and then gradually increase, during the initial treatment period in serum lithium concentration should be controlled at least once a week, the optimal concentration of lithium - from 0,5 to 0,8 mmol / l after pursuant the desired control tests kontsentratsiiyi can be done less frequently - Nitroglycerin every month or every two months; in remission serum lithium concentration can be determined every 2-3 months, with severe manic disorders Ductal Carcinoma in situ dose is 1,5-2,0 g / day, while the concentration of lithium serum should be between 0,6-1,2 mmol / l pursuant after relief of symptoms of Radian dose of lithium carbonate immediately decrease, the total daily dose of lithium carbonate need to take pursuant less than three reception, if one dose was missing, do not double the next dose. 50 mg, 100 mg, 300 mg, 400 mg cap.
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